Spironolactone

Brand Name Manufacturers

Aldactone by Searle
Spironolacton by ? in Bulgaria
Uractone by ? in Italy
Verospiron by ? in Hungary

Generic Manufacturers


Caremark
Cheshire
Geneva
Goldline
Heartland
Major
Moore, H.L.
Mutual
Mylan
Parmed
PD-RX
Purepac
Qualitest
Raway
Rugby
UDL
URL
Vanguard

Pharmacology

Mostly inhibits production of testosterone at the stage of 17-hydroxylation, and competes with DHT (dihydrotestosterone) for bonding at peripheral receptors. It is also said to intensify catabolism of androgens, and activate conversion of testosterone into estrogens.

Delivery

25, 50, 100mg oral tablets

Typical dosage

Pre-op 100-400mg/day
Post-op 50mg/day

Availability

Approved by U.S. FDA

Indications

Congestive heart failure. Elevated blood pressure. Fluid retention. Hyperaldasteronism. Inadequate pottasium retention. Liver cirrhosis.

Contraindications

Elevated potassium levels. Inadequate urine production. Kidney disfunction.

Adverse reactions

CNS

Confusion. Dizziness. Drowsiness. Headache. Lethargy. Loss of precise motor control.

Gastrointestinal

Cramping. Diarrhea. Dry mouth. Gastric ulceration and other stomach inflammation. Vomiting.

Skin

Acne. Itchy, fluid-filled patches of skin. Increase of body and facial hair. Red skin patches from capillary congestion.

Other

Deepening of the voice. Drug fever. Pottasium retention. Severe decrease of blood granulocytes. Sodium loss.

Comments

One person reported suicidal depression as an adverse effect. The brand-name formulation tastes awful; the generic formulation is much less offensive.