Brand Name Manufacturers

Synarel by Searle

Generic Manufacturers

None

Pharmacology

GnRH agonist. After an initial stimulating phase, The pituitary is desensitized to GnRH, which causes it to stop producing LH, which in turn dramatically decreases gonadal production of hormones within one month.

Delivery

Nasal spray

Typical dosage

Pre-op 1600mcg/day (2 sprays into each nostril twice a day)

Availability

Approved by U.S. FDA

Indications

Central precocious puberty. Endometriosis.

Contraindications

Hypersensitivity to GnRH, GnRH agonists analogs or any component of the product

Adverse reactions

CNS

Headache. Insomnia. Mental depression.

Skin

Acne. Body odor. Increase of body and facial hair. Itchiness. Itchy, fluid-filled patches of skin. Oily skin. Rash. Vaginal dryness.

Other

Chest pain. Fluid retention. Hot flashes. Muscle pain. Nasal irritation. Ovarian cysts. Shortness of breath. Vaginal bleeding.

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