Brand Name Manufacturers

Ogen by Pharmacia/Upjohn

Generic Manufacturers

Caremark
Duramed
Goldline
Ortho-est by Ortho Pharm
Qualitest
Rugby
Schein
URL
Warner Chilcott
Watson

Pharmacology

Sulfate of estrone, stabilized with piperazine. Apparently acts on receptors the same as endogenous estrogen.

Delivery

Oral 0.75, 1.5, 3mg tablets

Typical dosage

Pre-op ?
Post-op Oral 1.5-9mg/day

Availability

Approved by U.S. FDA

Indications

Estrogen replacement therapy in females

Contraindications

Active blood clotting disorders. Known or suspected breast cancer, unless that is the target. Known or suspected estrogen dependent tumors.

Adverse reactions

CNS

Dizziness. Headache. Mental depression. Migraine. Spasms of limb and facial muscles.

Eyes

Intolerance to contact lenses. Steepening of corneal curvature.

Gastrointestinal

Abdominal cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.

Skin

Blood eruptions from skin. Blotchy skin pigmentation. Increase of body and facial hair. Loss of scalp hair. Red skin patches from capillary congestion.

Other

Blood clotting disorders. Breast tumors. Elevated blood pressure. Fluid retention. Gall bladder disease. Increased calcium level in blood. Increased sensitivity to light. Reduced carbohydrate tolerance.

Comments

Since estropipate is a quot;natural estrogenic substance prepared from purified crystalline estrone", the source is likely to be pregnant mares, the same as for conjugated and esterified estrogens. Refuting or confirming evidence would be appreciated.